When comparing biliary vs. intestinal vs. ‘other’ type (i.e., squamous/adenosquamous carcinoma and signet ring cell/diffuse/undifferentiated carcinoma), significantly more class 4/5 TP53 alterations were observed in the biliary type adenocarcinoma cases (P = 0.000). Here, TP53 is linked to adenosquamous carcinoma.