Univariate Cox regression analysis showed that eGFR, Alb < 30 g/L, anemia, use of antibiotics, use of NSAIDs, occurrence of AKI, and nonrecovery of renal function after the occurrence of AKI were risk factors for death in patients treated with ICIs (P < 0.05) (Fig. 3). The gene discussed is ALB; the disease is anemia (phenotype).