TNF and myocardial infarction: We also found equal levels of TNF-α and IL-1β in WT and Dusp6-deficient CD45+/HIS48+ infiltrated neutrophils of hearts after MI (Supplementary Fig. 8b, c), suggesting that Dusp6 deficiency has no effect on the release of pro-inflammatory cytokines from neutrophils in both peripheral blood and infarcted heart tissue.