In line with the predominant abundance of DUSP6 in human granulocytes, DUSP6 was highly enriched in neutrophils from rat peripheral blood, the abdominal cavity, and infarcted LV tissue; and DUSP6 deficiency had no impact on neutrophil development, maturation, and tissue infiltration in LV infarct tissue in the post-MI phase. Here, DUSP6 is linked to myocardial infarction.