For example, CACNA1H, a voltage-gated calcium channel, has been detected in breast cancer56,82; RARA, a retinoic acid receptor alpha, has exhibited important roles in leukemia and recently in medulloblastoma and glioma83; and HSPB8 (heat shock protein beta-8) promotes glioma growth and metastasis61,84. The gene discussed is RARA; the disease is leukemia.