Functionally, some of the downregulated genes by hyperDMR have been associated with human cancers, including advanced stage of cancers (SMTN69 and DES70, BANK171), autophage related death and prognosis of pancreatic cancer (CYB5A)72,73 and aggressive phenotype of glioma and colorectal cancer recurrence (MFI2)74,75. This evidence concerns the gene CYB5A and central nervous system cancer.