The effects of LSD1 silencing are unique for mESCs and F9 cells, as silencing of LSD1 in human embryonic kidney carcinoma 293 T and lung carcinoma H1299 cells that express both SMARCC1 and SMARCC2 did not exhibit any proliferation defects (Supplementary Fig. 7c–e). Here, SMARCC2 is linked to lung carcinoma.