In pluripotent mouse embryonic stem cells (mESCs) and mouse F9 embryonic carcinoma cells, a unique mSWI/SNF complex, the esBAF complex, is assembled with limited key subunits, including BRG1 (SMARCA4 or BAF190A), the ATP-dependent chromatin remodeling catalytic subunit, SMARCC1 (BAF155 or SRG3), ARID1A (SMARCF1 or BAF250A), PBRM1 (Polybromo-1 or BAF180), and SMARCB1 (BAF47, INI1, or SNF5), to functionally associate with OCT4 and NANOG to regulate the central transcription circuitry of mESCs4–7. The gene discussed is PBRM1; the disease is embryonal carcinoma.