ARHGEF18 and retinal disorder: Among Malays, who are unrepresented in existing population databases, we found higher carrier burden for beta-thalassemia, contributed by the common Southeast Asian HBB c.79G > A (p.Glu27Lys; 6.72% Malays), and retinopathies driven by recurrent variants in retinopathy-related genes ABCA4 (Stargardt disease, c.71G > A (p.Arg24His), 2.36%) and ARHGEF18 (retinitis pigmentosa, c.826-1G > A, 1.80%).