SLC25A13 and citrin deficiency: Nevertheless, we observed a few genes with high carrier burden that are driven by high carrier frequencies in known causal variants for disorders, such as the significant burden of SLC25A13 in Chinese (2.29%, p = 2.51 × 10−14) due to a high carrier frequency of citrin deficiency-linked variant SLC25A13 c.852_855del (p.Met285Profs*2)24,25 (Chinese: 1.45%) and GNE in Indians (3.40%, p < 9.6 x 10-8)  attributed to the GNE myopathy-linked c.2086G>A (p.Val696Met) variant26 (Indian: 3.40%).