Only two individuals (2/309) had P/LP variants in multiple genes: one harbouring predisposition to familial hypercholesterolemia (FH) and long QT syndromes (PCSK9, KCNH2) and the other with predisposition to cancer and hypertrophic cardiomyopathy (SDHD, MYBPC3). Here, SDHD is linked to familial hyperaldosteronism.