NOTCH3 and Leukoencephalopathy: These genes are either associated with non-life-threatening disorders (FLG; ichthyosis vulgaris), late-onset disorders (NOTCH3; cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy, CADASIL) or risk factors for disease (PRSS1, CTRC; hereditary pancreatitis).