Notably, whereas cystic fibrosis is prevalent in European-descent populations and frequently associated with CFTR c.1521_1523delCTT (p.Phe508del) variant, this is rare in Asia where CFTR-related CBAVD and pancreatitis are more frequently observed together with CFTR c.1210-11T > G and Gln1352His variants45,46. This evidence concerns the gene CFTR and cystic fibrosis.