This yield increased to 3.41% with the expanded ACMG SF v3.0 list, identifying an additional 71 individuals, most of whom are protein-truncating variant carriers in the newly included cardiomyopathy gene TTN (53/71) and hereditary breast and ovarian cancer (HBOC) syndrome gene PALB2 (11/71). The gene discussed is TTN; the disease is cardiomyopathy.