It was revealed that TYRO3 prohibited the ferroptosis of tumor cells induced by anti-PD-1/PD-L1 via the AKT/NRF2 axis and amplified a pro-tumor microenvironment by downgrading the ratio of M1/M2 macrophages, consequently contributing to anti-PD-1/PD-L1 treatment [189]. Here, AKT1 is linked to neoplasm.