To determine the relationship between NCX2 and glioma aggressiveness and angiogenesis in hypoxia, RT-PCR was used to analyze the mRNA levels of MMP2, MMP3, MMP7, MMP14, TIMP1, VEGF, and PAI-1 to detect whether HIF-1 led to those gene changes. The gene discussed is SLC8A2; the disease is central nervous system cancer.