For this, we retrospectively correlated a predefined systemic inflammation score (SIS) based on the following systemic inflammatory response parameters (SIR): the modified Glasgow Prognostic Score (mGPS), neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and CRP with the response to systemic chemotherapy, progression-free survival, and overall survival in a cohort of patients with iCCA (Markus et al. 2021; McNamara et al. 2014; Okano et al. 2018; Proctor et al. 2011; Schweitzer et al. 2017). This evidence concerns the gene CRP and infantile convulsions and choreoathetosis.