Because of the reported role of IFNγ on pancreatic cells and its connection with the PD-L1 signaling,9,10,14,15 we assessed whether, similarly to tumor cells, pancreatic organoids (derived from the pancreas of C57BL/6 mice) expressed PD-L1 following IFNγ exposure and whether it leads to a metabolic rewiring toward aerobic glycolysis.8 Preparation of mouse pancreatic organoids was performed as depicted in Figure 1a and described in the methods. This evidence concerns the gene IFNG and neoplasm.