This process also causes the development of disordered and immature vasculature with damaged endothelial cell junctions, which is related to tumor interstitial fluid pressure, neo-vessel permeability, and fragility [155]. When there is an imbalance between proangiogenic factors, such as bFGF, VEGF, insulin-like growth factor 1 (IGF-1), angiopoietin-2, and hepatocyte growth factor (HGF); and antiangiogenic factors, such as angiopoietin-1 and thrombospondin-1, the development of blood vessels within tumors can occur [84]. Here, IGF1 is linked to neoplasm.