IL6 and metabolic dysfunction-associated steatohepatitis: We found that NASH progression, the induced hepatic proinflammatory IL-6, and the fibrosis feature were all markedly suppressed in Rig-Ihep−/− livers of MCD model (Fig. 5e, Additional file 2: Fig. S5d, e, f), and NASH features were also abolished in Rig-Ihep−/− mice of CD-HFD model (Additional file 2: Fig. S5g).