Interestingly, hepatocyte-specific RIG-I deficiency nearly abolished NASH-induced hepatocarcinogenesis, suggesting the tumor-promotive role of RIG-I in NASH-induced HCC, which is opposite to the tumor-suppressive role of RIG-I in the DEN model (Fig. 5a, b, Additional file 2: Fig. S5a, b). The gene discussed is RIGI; the disease is metabolic dysfunction-associated steatohepatitis.