Upon hepatic inflammation, inflammatory circumstances such as IL-6 promote JMJD4-mediated RIG-I demethylation at K18 and K146, thus restricting STAT3 activation and oncogenic transformation, and decreased RIG-I expression in liver cancer progenitor HcPCs enhances IL-6 effects and drives them to fully established HCC (Fig. 7m). Here, JMJD4 is linked to hepatocellular carcinoma.