For example, a current work reported that stress-induced IL-6 from brown adipocytes could enhance hepatic gluconeogenesis and hyperglycemia [35], which may be in line with our data that IL-6-induced demethylated RIG-I disassociates with AMPKα and may enhance HMGCR phosphorylation to suppress cholesterol synthesis. Here, HMGCR is linked to Hyperglycemia.