RIGI and metabolic dysfunction-associated steatotic liver disease: Although HMGCR phosphorylation differed between individuals and was not significantly changed in NAFLD livers (Additional file 2: Fig. S7d), HMGCR phosphorylation was significantly lower while serum cholesterol was significantly higher in the 8 NAFLD livers with increased RIG-I than in those without significantly increased RIG-I (Fig. 7i, j).