KEGG and GSEA analysis showed enhanced inflammatory immune responses in BD serum-induced macrophages, including phagosome, IL-17 signaling pathway, and TNF-signaling pathway (Fig. 3D–F), which was confirmed by the phagocytosis test (Fig. 1E), enhanced Th17 differentiation (Supplemental Figure S6), and overproduction of TNF-α in BD serum-treated macrophages (Fig. 1D), respectively. Here, TNF is linked to Behcet disease.