BD serum, but not HC serum, induced a significantly higher level of phosphorylated p65 (p-p65) (1.4 ± 0.3 vs 0.6 ± 0.2, p<0.05) and lower level of IκBα (0.8 ± 0.4 vs 1.2 ± 0.3, p<0.05) in macrophages (Fig. 4A) at 15 min. This evidence concerns the gene NFKBIA and Behcet disease.