We incubated naive CD4+ T cells with M0, M1, M2, BD, or HC serum-treated macrophages and observed that M1 macrophages and BD serum-treated macrophages (M0: 51.6 ± 7.1%, M1: 82.1 ± 8.8%, MBD: 66.7 ± 5.3%) promoted more IFNγ+CD4+ T cell differentiation than M0 macrophages (Fig. 2, Supplemental Figure S4). This evidence concerns the gene CD4 and Behcet disease.