Leonurine down-regulates miR-18a-5p and enhances SOCS5 expression to curb JAK2/STAT3 signaling pathway activation, impeding CML cells’ proliferation, migration, and colony formation, boosting their apoptosis, and thus exerting a prominent anti-leukemia function in chronic myeloid leukemia [38]. This evidence concerns the gene STAT3 and chronic myelogenous leukemia, BCR-ABL1 positive.