AIF1 and brain ischemia: Furthermore, a previous study demonstrated that MFA in cerebral ischemia and reperfusion model increased the expression of anti-apoptotic proteins such as Bcl-xl and Bcl-2 and decreased Bax concentrations, improving energy metabolism and response to the inflammatory process, which may be related to the decrease in microglia activity, such as the decrease in Iba-1 [17, 34].