According to the revised International Autoimmune Hepatitis Group scoring system, our patient’s pretreatment score is 17 (+2 for female, +2 for ALP/AST <1.5, +2 for IgG 1.5–2 times above normal, +3 for ASMA/ANA >1:80, +3 for negative viral marker, +1 for no drugs, +2 for alcohol < 25 g/day, +2 for other immune diseases), which along with her normal complement levels and fulfillment of the EULAR/ACR criteria for SLE 2019, is highly suggestive of an overlap syndrome. This evidence concerns the gene BTG3 and systemic lupus erythematosus.