Insulin-like growth factor-2 mRNA–binding protein (IGF2BP) family members as a kind of RNA-binding proteins participated in tumorigenesis as well as chemoresistance via influencing either stability, translatability, or localization of lncRNA [70–72].IIt has been found that TUG1 and IGF2BP2 were both high-expressed in CRC cell resistant to cisplatin through autophagy activation. The gene discussed is IGF2BP2; the disease is colorectal carcinoma.