CD28 and neoplasm: However, the other subtypes of PBLs before chemotherapy including the tumor-suppressive subtype (CD8+CD107a+ T cells, CD8+CD28+ T cells) and tumor-promoting subtypes (CD4+CD25+FOXP3+ Tregs, CD8+CTLA4+ T cells, CD8+CD122+ T cells, CD8+CD45R+ T cells) showed no significant correlation with the prognosis of patients with MPC both in correlation analysis and in the Kaplan–Meier method with log-rank test (Fig. 3).