Namely, for patients with CP-B7 cirrhosis, it is important for the clinician to contextualize the patient’s CP-B7 liver function by considering the patient’s history as well as what specific factors deem their categorization into the CP-B7 class; such considerations include the time-course to which they progressed to have CP-B7 liver function, whether the patient has had previous HCC-directed interventions, how other liver-directed treatments were tolerated, and other comorbidities or physiologic processes contributing to fluctuating serum markers. The gene discussed is CP; the disease is hepatocellular carcinoma.