CEBPA and acute myeloid leukemia: This finding is entirely consistent with the fact that the CEBPAN/C GRN (i) contains C/EBP proteins as a major node, (ii) that a large number of genes are bound by the mutant protein, including C/EBPAN/C-AML-specific cis-elements, (iii) that the latter are associated with downregulated myeloid differentiation genes and (iv) that eliminating this node using dnC/EBP affects the survival of the cells.