We previously defined the gene regulatory networks (GRNs) of seven AML subtypes including t(8;21), Inv(16), FLT3-TKD, FLT3-ITD, NPM1, RUNX1, biallelic CEBPAN/C and CEBPA single mutations by collecting transcriptome, digital footprinting and chromatin conformation capture data [4]. The gene discussed is FLT3; the disease is acute myeloid leukemia.