Taken together, these findings suggest that ferrichrome inhibits pancreatic tumor growth in a manner that is not intrinsic to the cancer cell, but through the modulation of immune milieu of the TME, potentially by decreasing macrophage-induced immunosuppression and by inducing a potent CD8 + T cell-mediated antitumor immune response. The gene discussed is CD8A; the disease is pancreatic neoplasm.