When considering the 72 significantly mutated promoters, we found mutations of known CLL drivers including BIRC3 (n = 31, 6.4%, FDR < 1.15 ×10−15), IKZF3 (n = 12, 2.5%, FDR = 8.16 × 10−13) and TP53 affecting splicing regions of noncoding exons/5′ UTR/promoter region (n = 2, 0.4%, FDR = 5.55 × 10−6). This evidence concerns the gene BIRC3 and B-cell chronic lymphocytic leukemia.