When considering u-IGHV CLL (Fig. 8c and Supplementary Table 23), u-GS1 was characterized by the presence of high-risk features including TP53 disruption, GC7, short telomeres and mutations in targetable pathways such as MAPK, PI3K and apoptosis, but there was no DNA damage response signature. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.