SMCHD1 and neoplasm: Similarly, SMCHD1 (structural maintenance of chromosomes flexible hinge domain containing 1), previously reported as a candidate tumor suppressor in hematopoietic cancers25 was affected by copy number losses (del18p11.32-p11.31) (Fig. 3g) and truncating SNVs/indels with high CCFs (Fig. 3h) (n = 24/485, 5.0%).