We detected 993 translocations, of which two occurred in more than ten samples and affected known genes with no previously documented role in CLL, including t(14;22) with breakpoints within WDHD1 (n = 12, 2.6%) and t(5;6) (CTNND2-ARHGAP18, n = 11, 2.4%) (Fig. 1e and Extended Data Fig. 2c). The gene discussed is ARHGAP18; the disease is B-cell chronic lymphocytic leukemia.