Given the small number of available cells, we selected ABEmax/KLF1_bs_1 sgRNA to create the KLF1 profile (which had given the greatest HbF reactivation in SCD samples) and CBE-SpRY/LRF_bs_2 sgRNA to create the LRF 8C profile (which contained more HPFH- and HPFH-like mutations than LRF 4C and LRF 2T). Here, KLF1 is linked to Schnyder corneal dystrophy.