APOE and Alzheimer disease: The AD risk genes are implicated in the immune response (CLU, CR1, CD33, EPHA1, MS4A4E/MS4A6A, ABCA7, PTK2B, TREM2, and TREML2), endocytosis (BIN1, PICALM, and CD2AP), and lipid processing (APOE, ABCA7, and SORL1)17,18.