In contrast, both Rag1−/−; Dmp1-Cre; Myd88fl/fl and Dmp1-Cre;Ranklfl/fl mice exhibited a significant rescue from alveolar bone osteolysis, thereby confirming that osteocytes are the primary source of RANKL in Pg-induced periodontitis. Here, TNFSF11 is linked to periodontitis.