Considering the finding that Dmp1-Cre deletes and restores MYD88 selectively in Ocy, it is conceivable that the MYD88 pathway in osteocytes rather than that in osteoblasts is playing a major role in regulating osteoclast formation induced by PAMPs in calvarial osteolysis and Pg-driven periodontitis models. Here, MYD88 is linked to periodontitis.