As Dmp1-Cre;Myd88fl/fl mice infected with Pg show a rescue from alveolar bone loss and Dmp1-Cre;Myd88lsl/lsl mice infected with Pg exhibit alveolar bone loss, we propose that direct activation of the alveolar bone osteocytes by bacterial PAMPs is a pathological mechanism of periodontal bone loss and the MYD88 pathway would be a treatment and prevention target for periodontal diseases. Here, MYD88 is linked to periodontal disorder.