MAPK8 and familial dilated cardiomyopathy: Genes upregulated in both Lmna-/- mESC-derived CMs and DCM patients were linked to muscle contraction (Fig. 5h), while genes upregulated in Lmna knockdown CMs and DCM patients were linked to intracellular signal transduction, JNK activity and ER stress (Fig. 5i).