ACTN2 and familial dilated cardiomyopathy: Interestingly, among the genes overlapping between patients with pathogenic LMNA mutations and upon lamin A/C depletion in mESCs but not in CMs we found many genes associated with DCM, e.g., RBM20, LDB3, ACTN2, MYOM1, MYL2, etc. Downregulated genes in both cases were enriched for genes linked to mitotic cell cycle and cell division (Fig. 5h, i).