LMNA and Hutchinson-Gilford progeria syndrome: In contrast to lamin A/C deficiency, ESC lines harboring the Lmna p.H222P mutation, causing Emery-Dreifuss muscular dystrophy and cardiomyopathy20, and the Lmna p.G609G mutation, resulting in Hutchinson-Gilford progeria syndrome (accelerated aging and premature death due to cardiovascular events)21,22 showed different differentiation behavior (Supplementary Fig. 2a–f).