LMNA and non-compaction cardiomyopathy: In line with the cell-culture-based phenotype, Lmna-deficient and haploinsufficient embryos showed increased expression of pioneer cardiac TFs38,40 during early cardiogenesis, increased expression of CM-specific structural and contraction genes, hypercontractility as well as precocious binucleation, decreased proliferation and non-compaction cardiomyopathy.