SMC5 and microcephalic primordial dwarfism: Consistent with the elevated levels of spontaneous replication stress, LCLs derived from SLF2 and SMC5 mutant patients all exhibited increased levels of chromosomal aberrations (such as chromosome and chromatid gaps/breaks and chromosome radials) comparable to that observed in an ATR-Seckel Syndrome LCL (Fig. 6f, g).