Our in vivo studies revealed that cardiomyocyte-specific deletion of MTFP1 (cMKO) drives the progressive development of dilated cardiomyopathy (DCM) beginning at 18 weeks of age culminating in chronic heart failure (Fig. 1g–l, S1f–k) and middle-aged death in both male and female mice (Fig. 1f, S1e). This evidence concerns the gene MTFP1 and congestive heart failure.