After GO analysis of the seventy-four genes, six secreted cytokines related to cell cycle, proliferation and apoptosis including CSF2, CTF1, FGF2, IGF2, HGF and LIF were selected for PCR verification and FGF2 was confirmed to be significantly up-regulated in leukaemia mice derived MSCs (Fig. 4D). The gene discussed is IGF2; the disease is leukemia.