However, after addition of BGJ398 or FGF2 knockdown, the expression of phosphorylation of PI3K/AKT/mTOR proteins were significantly reduced (Fig. 4H), indicating that FGF2/FGFR2 combination activated PI3K/AKT/mTOR pathway in leukaemia cells. This evidence concerns the gene FGFR2 and leukemia.