However, after addition of BGJ398 or FGF2 knockdown, the expression of phosphorylation of PI3K/AKT/mTOR proteins were significantly reduced (Fig. 4H), indicating that FGF2/FGFR2 combination activated PI3K/AKT/mTOR pathway in leukaemia cells. The gene discussed is AKT1; the disease is leukemia.