Realtime PCR results revealed that the expression of cell cycle and apoptosis associated genes, such as P21, P27, CCND1, CDK2, BAX, BAD and BCL2 were altered in primary T-ALL cells after FGF2 and FGFR2 blockade (Fig. 5G, H). This evidence concerns the gene CCND1 and acute lymphoblastic leukemia.