CERT1 and colonic neoplasm: In addition, knockdown of CERT sensitizes HCT-116 human colon cancer cells, BT474, HCC1954 and SK-BR3 HER2 + breast cancer cell lines, MDA-MB-231 human triple-negative breast cancer cells and A549 human lung carcinoma cells to apoptosis induced by chemotherapeutic agents [60, 62].