Further, soluble Aβ levels, measured as the CSF ratio of Aβ42/40, were not related to the accumulation of tau aggregates (β = 0.07, p = 0.55 for tau-PET rate of change in Q1) or cognitive decline (β = −0.21, p = 0.10 for MMSE slope). This evidence concerns the gene MAPT and Mental deterioration.