We observe a full mediation effect of tau-PET rate of change, either in Q1 or in the temporal meta-ROI between soluble p-tau and cognitive decline on the cognitive composite score in CU (c’-c = −0.21 [−0.40, −0.06], p = 0.002), and on decline on MMSE in MCI (c’-c = −0.24 [−0.46, −0.04], p = 0.01), see Supplementary Fig. 12 for detailed statistics. This evidence concerns the gene MAPT and Mental deterioration.