Firstly, the GPR35 expression level was positively correlated with signature genes expression level for angiogenesis promotion (VEGF, CXCL1, TGFA, ANG, and Dll4), cell proliferation (Myc, PTEN, AKT, HSP90, and GSK3B) and cell apoptosis inhibition (BCL-xl, Bcl-W, Mcl-1, and 14-3-3) in GC (Fig. 5B). This evidence concerns the gene DLL4 and gastric cancer.