GPR35 and gastric cancer: To explore the molecular features of macrophage which is affected by GPR35, we downloaded single-cell RNA sequencing data in gastric antral mucosa biopsies of patients spanning a cascade of gastric premalignant lesions and early gastric cancer (EGC) from the NCBI GEO database (GSE134520) [17] (supplementary Figs. S6B, C).