Then, we found GPR35 expression level has a positive relationship with promoting effects on hallmarks of cancer, especially escape apoptosis signatures (YTHDF2, PUS10, DCK1, ADAR1, and TUT1, r = 0.35, p = 1.91e-13) and achieve replicative immortality signatures (DKC1 and ADAR1, r = 0.32, p = 6.30e-13) (Supplementary Fig. S3B). This evidence concerns the gene GPR35 and cancer.