For spontaneous and colitis-associated colon cancers, activation of the GPR35 pathway promotes tumor development mainly via two separate routes: one way to do is by directly augmenting proliferation in epithelial cells that express the receptor; other way to do is by coordinating macrophages’ ability to create a tumor-permissive environment [14, 15, 21]. Here, GPR35 is linked to malignant colon neoplasm.