PTEN and gastric cancer: Firstly, the GPR35 expression level was positively correlated with signature genes expression level for angiogenesis promotion (VEGF, CXCL1, TGFA, ANG, and Dll4), cell proliferation (Myc, PTEN, AKT, HSP90, and GSK3B) and cell apoptosis inhibition (BCL-xl, Bcl-W, Mcl-1, and 14-3-3) in GC (Fig. 5B).