First, the SP1 motif is necessary for MACC1-mediated MET expression in colon cancer cells [31], which suggests that MACC1 regulation of MET requires involvement with SP1; in terms of this, MACC1 may not interact with SP1 and therefore does not regulate pancreatic cancer metastasis via the MET pathway. This evidence concerns the gene MACC1 and malignant colon neoplasm.