MACC1 and neoplasm: Subsequently, MACC1 has been further regarded as a prognostic biomarker for multiple solid cancers, such as pancreatic, esophageal, gastric, lung, hepatobiliary, breast, ovarian, nasopharyngeal, and renal cancers and glioblastomas, and its expression level is positively associated with tumor progression, metastasis development and patient survival [6–12].