First, the SP1 motif is necessary for MACC1-mediated MET expression in colon cancer cells [31], which suggests that MACC1 regulation of MET requires involvement with SP1; in terms of this, MACC1 may not interact with SP1 and therefore does not regulate pancreatic cancer metastasis via the MET pathway. The gene discussed is SP1; the disease is familial pancreatic carcinoma.