Not surprisingly therefore, adding the SLC30A8 variant genotype to the FPG-GRS predictions had a marked impact (Table 2 and Fig. 4a): for example, the T2D prevalence for the top decile of the FPG-GRS fell from 14.2% overall to 7.3% in carriers; and from 6.1% to 3.7% in the bottom decile (Table 2 and Supplementary Fig. 10). The gene discussed is SLC30A8; the disease is type 2 diabetes mellitus.