HPSC-derived annexin 6A-positive (ANXA6+) EVs containing the annexin A6/LDL receptor-related protein1/thrombospondin1 (ANXA6/LRP1/TSP1) complex promote pancreatic cancer aggressiveness following tumor cell uptake and depletion of ANXA6 in cancer associated fibroblasts impairs tumor metastasis (26). This evidence concerns the gene ANXA6 and familial pancreatic carcinoma.