HPSC-derived annexin 6A-positive (ANXA6+) EVs containing the annexin A6/LDL receptor-related protein1/thrombospondin1 (ANXA6/LRP1/TSP1) complex promote pancreatic cancer aggressiveness following tumor cell uptake and depletion of ANXA6 in cancer associated fibroblasts impairs tumor metastasis (26). The gene discussed is ANXA6; the disease is cancer.