In their paper, pathogenic variants were identified by whole-exome sequencing (WES) in most ARCI-associated genes, including TGM1 (21%), CYP4F22 (18%), ALOX12B (14%), ABCA12 (10%), ALOXE3 (6%), NIPAL4 (5%), PNPLA1 (3%), LIPN (2%), and SDR9C7 (2%) (15). Here, CYP4F22 is linked to autosomal recessive congenital ichthyosis.