In this regard, studying the modulatory effects of miRNAs and lncRNAs on those glycolytic proteins linked with cancer progression, e.g., HK1, GAPDH, PKM2, GLUT1, GLUT3, HIF-1α, CAV1, Ras, HK2, LDHA, PGI/AMF, and PFKFB3 [174,175,177], might be very favorable for the design of novel treatments for PC. This evidence concerns the gene HK1 and pachyonychia congenita.