MORC2 and microcephaly: Recently, MORC2 mutations have been reported in individuals with Charcot-Marie-Tooth (CMT) disease type 2Z, a form of axonal neuropathy with progressive muscle weakness, atrophy, and sensory impairment (15–17) and in a neurodevelopmental disorder with intellectual disability, growth retardation, microcephaly, and variable craniofacial dysmorphism (18).