Since it has been well established that CD36 is associated with insulin resistance, hepatic steatosis and inflammation [53–56], and obesity-related lipotoxicity [57], the upregulation of CD36 as a result of GPR40 KO is likely to play a pivotal role in GPR40 KO-promoted hepatic steatosis, inflammation and fibrosis in LDLR-deficient mice. The gene discussed is LDLR; the disease is obesity due to melanocortin 4 receptor deficiency.