In subjects with T2DM not taking insulin secretagogues (sulfonylureas/glinides), the serum SerpinB1 levels were negatively correlated with FBG (β = -0.449, P = 0.007), and tended to be associated with higher HOMA2-%S (β = 0.345, P = 0.051) after adjusting for age and sex (S6 Table in S1 File). The gene discussed is SERPINB1; the disease is type 2 diabetes mellitus.