AGER and Immunodeficiency: In a previous study, we determined that an excess of soluble RAGE (sRAGE, or RAGE that has been cleaved from the cell membrane) acts as a dead-end for inflammatory signals in the alveolar space, binding ligands without allowing their normal processing and propagation.25 The function of the excess sRAGE in HIV has yet to be determined but may present a further interesting avenue for investigation of HIV-induced innate immune deficiency.