TP53 and cancer: Many cell signaling pathways related to cancer development, such as PI3K-Akt signaling pathway [35, 36], Ras signaling pathway [37–40], STAT signaling [40–43], MAPK signaling pathway [35, 37], TGF-beta signaling pathway [44, 45], NOTCH signaling pathway [46–49], p53 signaling pathway [50–52], cAMP signaling pathway [53, 54], Hippo signaling pathway [55, 56], Wnt signaling pathway [57], and so on.