SPTAN1 and hereditary spastic paraplegia: A case-control analysis revealed a statistically significant enrichment of rare probably damaging heterozygous variants of SPTAN1 in probands with HA or HSP (12/1142 cases vs 52/23,847 controls, p = .00002846, odds ratio = 4.8594, 95% CI = 2.5867-9.1290) (Supplemental Table 1).