Genes in cluster 0 (blue) included JUN, JUNB, FOS, FOSB and ATF, which together form the AP-1 transcription factor, and the MAPK signaling genes DUSP1 and DUSP2, both of which control cellular differentiation and proliferation during viral infection (73) along with EGR2, which is also expressed by cluster 0 (74, 75). The gene discussed is FOSB; the disease is viral infectious disease.