Considering the change in ASMI from baseline to 12 months (ΔASMI), spearman correlation analysis showed that baseline serum myostatin level was negatively correlated with ΔASMI in all (r=-0.193, P<0.001, Figure 1J) and female RA patients (r=-0.225, P<0.001, Figure 1K), without significant correlation in male RA patients (Figure 1L). The gene discussed is MSTN; the disease is rheumatoid arthritis.