Further gender stratification analysis showed that both female and male RA patients had higher levels of serum myostatin than corresponding healthy controls (female: 3.121 ± 1.607 ng/ml vs. 1.376 ± 0.580 ng/ml, Figure 1B; male: 3.872 ± 1.910 ng/ml vs. 2.717 ± 0.821 ng/ml, Figure 1C), although lower ASMI (female: 5.8 ± 0.7 kg/m2vs. 6.0 ± 0.5 kg/m2; male: 7.0 ± 0.9 kg/m2vs. 7.8 ± 0.7 kg/m2, all P<0.001). This evidence concerns the gene MSTN and rheumatoid arthritis.