Compared the baseline characteristics with other three subgroups, RA patients with high myostatin overlapping myopenia showed the highest radiographic assessment index including mTSS (median 26 vs. 3 vs. 10 vs. 10), JSN subscore (median 11 vs. 0 vs. 4 vs. 3), JE subscore (median 16 vs. 2 vs. 5 vs. 5), and the highest HAQ-DI (0.3 vs. 0.1 vs. 0.3 vs. 0.1), accompanied with the lowest proportion of female (77.6% vs. 89.7% vs. 90.6% vs.78.1%, all P<0.05, Table 3). The gene discussed is MSTN; the disease is rheumatoid arthritis.