Univariate analyses revealed that the severe HT after lymphodepletion chemotherapy (OR: 8.500; 95% CI: 2.299-31.431; P=0.001), grade of CRS (OR: 2.697; 95% CI: 1.152-6.312; P=0.022) and the levels of several serum biomarkers (including peak levels of IL-6 (OR: 1.008; 95% CI: 1.001-1.015; P=0.025), IL-8 (OR: 1.011; 95% CI: 1.002-1.020; P=0.019), IFNγ (OR: 1.036; 95% CI: 1.002-1.072; P=0.040), and MIP1α (OR: 1.066; 95% CI: 1.000-1.137; P=0.049) were significantly associated with the incidence of PHT. Here, CXCL8 is linked to congenital rubella syndrome.