In mouse tumor models, tumor antigen-specific CD8 T cell responses were often studied using immunodominant antigens such as AH1 and PMEL (31, 32) or model antigens such as ovalbumin (OVA) that can be introduced into tumors, and their corresponding transgenic T cells such as 1D4 and Pmel-1 (33, 34) or OT-I T cells (35). This evidence concerns the gene PMEL and neoplasm.