When transcriptomes coupled with TCR clonotypes, our results suggest two scenarios for successful anti-tumor immune responses in R: (1) top expanded TIL TCR clonotypes have a higher chance to reach the highest activation cluster A7 in R, which expressed the highest level of Ifng, Nr4a1, Nr4a3, Ccl4 and Xcl1; (2) top expanded TIL TCR clonotypes appeared to occupy both A6 and A5 clusters in R but were significantly skewed to A6 cluster in NR. The gene discussed is CCL4; the disease is neoplasm.