Furthermore, majority of top TCR clonotypes were detected in only one recipient, indicating a highly individualized anti-tumor immune response against the same tumor cell line (5); R and NR CD8 TILs did not differ greatly in transcriptional activation except that R or NR CD8 TILs more frequently occupied distinct activation clusters (6); individual markers were identified to correlate with R or NR status in CD8 TILs with top expanded TCR clonotypes. Here, CD8A is linked to neoplasm.