IFNG and neoplasm: Also, it is reported that IFNγ produced within tumors suppresses VEGFR3 expression by acting directly on tumor vessel endothelial cells and on the tumor-infiltrating lymphocytes to indirectly alter endothelial cells’ VEGFR3 expression (24). Consistent with this effect, previous work from our laboratory has demonstrated a significant reduction in the number of blood vessels present in B16 and EL-4 tumors after systemic expression of IL-12 (25).