As we have reported, a rapid and strong antitumor effect early after IL-12+IL-18 expression (27), we speculated that TVM (CD8+ CD44hi CD122hi CD49dlo) along with tumor Ag-specific CD8+ effector T cells (TEFF) and TMEM (CD8+ CD44hi CD122hi CD49dhi) could be playing a role in tumor growth control in an Ag-independent manner. Here, CD8A is linked to neoplasm.