Acetylcholine causes an increase in intracellular Ca2+ levels in CML-derived K-562 cells, and the α7-nAChR antagonist methyllycaconitine citrate inhibits K-562 cell proliferation as well as reduces the intracellular Ca2+ levels (177). Here, CHRNA7 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.