In B-ALL cell lines, VDAC1 was upregulated after prednisolone treatment in three steroid-sensitive cell lines (697, Sup-B15, RS4;11) but unchanged in the steroid-resistant cell line (REH), suggesting that VDAC1 has a role in steroid-induced apoptosis (190). This evidence concerns the gene VDAC1 and acute lymphoblastic leukemia.