Bioinformatic analysis of Oncomine, a web-based cancer microarray database of patient tissue revealed increased expression of CACNA transcripts in diverse cancer types including of CACNA1S and CACNA1C (coding for CaV1.1 and CaV1.2 channels respectively) in AML and B-ALL samples and of CACNA1A (coding for CaV2.1) in samples from patients with CLL, marginal zone lymphoma and monoclonal gammopathy of unknown significance (136, 137). Here, CACNA1S is linked to B-cell chronic lymphocytic leukemia.