TRPV1 and acute lymphoblastic leukemia: TRPV1 activation by resiniferatoxin (an analog of capsaicin, a vanilloid agonist) induces apoptosis, interferes with cell cycle progression and decreases proliferation in both Jurkat T-cells and patient-derived T-ALL lymphoblasts; however, the affect of resiniferatoxin on non-leukemic cells was not tested (172).