CD8A and head and neck squamous cell carcinoma: We uploaded RNA-seq data of TCGA-HNSCC patients onto CIBERSORT and found that HNSCCs with PIK3CAAmp/TP53mut have significantly lower expression of gene signatures for CD8 T cells and activated natural killer (NK) cells but significantly higher expression of macrophage gene signature, compared with HNSCCs lacking both mutations (14).